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Exp Biol Med (Maywood). 2018 Sep;243(13):1027-1036. doi: 10.1177/1535370218806828. Epub 2018 Oct 15.

Identification of miR-708-5p in peripheral blood monocytes: Potential marker for postmenopausal osteoporosis in Mexican-Mestizo population.

Author information

1
1 Laboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City C.P. 14610, Mexico.
2
2 Consejo Nacional de Ciencia y Tecnología (CONACYT)-Laboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City C.P. 14610, Mexico.
3
3 Laboratorio Nacional de Genómica para la Biodiversidad (Langebio), Unidad de Genómica Avanzada, Centro de Investigación y de Estudios Avanzados (CINVESTAV), Irapuato C.P. 3682, Mexico.
4
4 Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Avenida Universidad 655, Morelos C.P. 6210, Mexico.
5
5 Centro de Investigación en Políticas, Población y Salud, Facultad de Medicina, Universidad Nacional Autónoma de México, Circuito Cultural s/n Ciudad Universitaria, Mexico City C.P. 04510, Mexico.

Abstract

This is the first study in which hsa-miR-708-5p has been identified in peripheral blood monocytes (osteoclast precursors) and associated with postmenopausal osteoporosis through small RNA-Sequencing, in an Admixed Mexican Mestizo population. By conducting in silico and bioinformatic analyzes, we identified target genes and important signaling pathways involved in bone metabolism pointing hsa-miR-708-5p as a candidate marker for osteoporosis in Mexican population. These approaches provide a landscape of the post-transcriptional regulation, which can be useful for the management of postmenopausal osteoporosis along with the potential use of microRNAs as markers for its early detection.

KEYWORDS:

biomarkers; genomics; microRNAs; monocyte; osteoporosis; small RNA sequencing

PMID:
30322266
PMCID:
PMC6434455
DOI:
10.1177/1535370218806828
[Indexed for MEDLINE]
Free PMC Article

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