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Mol Cell Oncol. 2018 May 29;5(5):e1435185. doi: 10.1080/23723556.2018.1435185. eCollection 2018.

Leptin revisited: The role of leptin in starvation.

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Department of Internal Medicine, Yale University School of Medicine, New Haven, CT.


Starvation causes reductions in plasma leptin concentrations, but the physiologic impact of this observation had not been documented in the starved state. Here we discuss our recent work demonstrating that hypoleptinemia activates the hypothalamic-pituitary-adrenal (HPA) axis, increasing white adipose tissue (WAT) lipolysis and mediating a shift from glucose to fat metabolism to maintain euglycemia in fasted rats.


Acetyl-CoA; Corticosterone; Gluconeogenesis; Leptin; Lipolysis; Starvation; Systems biology studies in molecular and cellular oncology

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