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Dev Cell. 2018 Sep 10;46(5):527-528. doi: 10.1016/j.devcel.2018.08.017.

Pericentrin Knocks Down Cilia in Trisomy 21.

Author information

1
Department of Molecular, Cellular, and Developmental Biology, Yale University, 219 Prospect Street, New Haven, CT 06511, USA. Electronic address: david.breslow@yale.edu.

Abstract

Down syndrome is a developmental disorder caused by chromosome 21 trisomy, whereas ciliopathies result from defective primary cilia. In this issue of Developmental Cell, Galati et al. (2018) establish a link between these diseases, finding that cilium function is compromised in Down syndrome as a result of increased Pericentrin expression.

PMID:
30205034
DOI:
10.1016/j.devcel.2018.08.017
[Indexed for MEDLINE]

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