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Trends Cancer. 2018 Aug;4(8):553-566. doi: 10.1016/j.trecan.2018.06.004. Epub 2018 Jul 3.

Epigenetic Mechanisms Dictating Eradication of Cancer by Natural Killer Cells.

Author information

1
Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA.
2
Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA; Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address: narendra.wajapeyee@yale.edu.

Abstract

Natural killer (NK) cells of the innate immune system are the first line of defense against infectious agents and cancer cells. However, only a few mechanisms that regulate eradication of tumors by NK cells have been identified. In this review, we present an account of epigenetic mechanisms that modulate the ability of NK cells to eradicate cancer cells. To date, several drugs that target epigenetic modifiers have shown clinical efficacy in cancer. Therefore, once a given epigenetic modifier is validated as a regulator of NK cell function, it can be targeted for NK cell-based cancer immunotherapies.

PMID:
30064663
PMCID:
PMC6085095
DOI:
10.1016/j.trecan.2018.06.004
[Indexed for MEDLINE]
Free PMC Article

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