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Methods Mol Biol. 2018;1831:17-24. doi: 10.1007/978-1-4939-8661-3_2.

Generation of Ultra-Small PLGA Nanoparticles by Sequential Centrifugation.

Author information

1
Department of Neurosurgery, Yale University, New Haven, CT, USA.
2
Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
3
Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, TX, USA. toral.patel@utsouthwestern.edu.

Abstract

Direct, local delivery of polymer nanoparticles to the brain is a promising strategy to bypass the blood-brain barrier (BBB) and safely deliver a large therapeutic payload. However, even with the aid of convection-enhanced delivery (CED) techniques, this approach has been limited by the inability to fabricate appropriately sized polymer nanoparticles. Here, we outline a versatile and efficient method for producing polymer nanoparticles that are <100 nm in diameter and can be delivered to the brain via CED.

KEYWORDS:

Blood-brain barrier; Brain; Convection-enhanced delivery; Nanoparticle; PLGA; Polymer

PMID:
30051421
DOI:
10.1007/978-1-4939-8661-3_2
[Indexed for MEDLINE]

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