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Transpl Infect Dis. 2018 Oct;20(5):e12966. doi: 10.1111/tid.12966. Epub 2018 Aug 23.

Successful treatment of primary donor-derived human herpesvirus-8 infection and hepatic Kaposi Sarcoma in an adult liver transplant recipient.

Author information

1
Departments of Surgery, Yale School of Medicine, New Haven, Connecticut.
2
Departments of Medicine, Yale School of Medicine, New Haven, Connecticut.
3
Departments of Pathology, Yale School of Medicine, New Haven, Connecticut.

Abstract

Kaposi sarcoma (KS) may rarely occur in transplant recipients through primary human herpesvirus-8 (HHV-8) infection from a seropositive donor. This report describes a patient who developed hepatic KS after receiving a split liver transplant from an HHV-8-positive donor. The recipient was treated with liposomal doxorubicin after reduction in immunosuppression led to acute cellular rejection. This treatment achieved regression of KS while preserving allograft function, demonstrating a successful therapeutic strategy for this malignancy.

KEYWORDS:

human herpesvirus-8; liver transplant; post-transplant Kaposi Sarcoma

PMID:
30014622
DOI:
10.1111/tid.12966
[Indexed for MEDLINE]

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