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Neuropsychobiology. 2017;76(4):193-198. doi: 10.1159/000490071. Epub 2018 Jul 2.

Association between Polymorphisms of the DRD2 and ANKK1 Genes and Suicide Attempt: A Preliminary Case-Control Study in a Mexican Population.

Author information

1
Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.
2
Hospital General de Yajalón, Secretaría de Salud, Yajalón, Mexico.
3
División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Mexico.
4
Hospital Psiquiátrico Infantil Juan N. Navarro, Secretaría de Salud, Mexico City, Mexico.
5
División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Mexico.
6
División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, Mexico.

Abstract

BACKGROUND:

The aim of this study was to analyze the possible association of polymorphic variants of the DRD2 and ANKK1 genes with suicide attempt in a Mexican population.

METHODS:

We conducted a case-control study in 289 subjects (166 suicide attempters and 123 healthy controls). We genotyped 2 polymorphisms of DRD2 (rs6275 and rs1799978) and 1 polymorphism of ANKK1 (rs1800497); then we analyzed the association between suicide attempt and these polymorphisms through genotypes, alleles, and inheritance models.

RESULTS:

Individuals who carried the TT genotype of the rs1800497 showed a 3-fold risk of attempting suicide (OR = 3.01; 95% CI 1.56-5.81, p = 0.001) when evaluated through the recessive model. In an analysis stratified by gender, this risk factor remained present among females (OR = 2.81; 95% CI 1.37-5.75) as well as males (OR = 3.3; 95% CI 1.01-10.77).

CONCLUSION:

Our results suggest that the rs1800497 variant of the ANKK1 gene could increase the risk of suicide attempt in a Mexican population. However, further studies using larger samples are necessary to obtain more conclusive results.

KEYWORDS:

ANKK1 gene; DRD2 gene; Dopamine; Gene; Suicide

PMID:
29966133
DOI:
10.1159/000490071

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