Format

Send to

Choose Destination
Breast Cancer Res Treat. 2018 Sep;171(2):247-259. doi: 10.1007/s10549-018-4850-7. Epub 2018 Jun 9.

New emerging roles of microRNAs in breast cancer.

Author information

1
Epigenetics Laboratory, Instituto Nacional de Medicina Genómica, Periferico Sur 4809, Arenal Tepepan, 14610, Mexico, CDMX, Mexico.
2
Laboratory of Connective Tissue, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra". Calz., México-Xochimilco 289, Arenal de Guadalupe, 14389, Mexico, CDMX, Mexico.
3
Functional Genomics Laboratory, Instituto Nacional de Medicina Genómica, Periferico Sur 4809, Arenal Tepepan, 14610, Mexico, CDMX, Mexico.
4
Epigenetics Laboratory, Instituto Nacional de Medicina Genómica, Periferico Sur 4809, Arenal Tepepan, 14610, Mexico, CDMX, Mexico. vmaldonado@inmegen.gob.mx.

Abstract

BACKGROUND:

MicroRNAs constitute a large family of non-coding RNAs, which actively participate in tumorigenesis by regulating a set of mRNAs of distinct signaling pathways. An altered expression of these molecules has been found in different tumorigenic processes of breast cancer, the most common type of cancer in the female population worldwide.

PURPOSE:

The objective of this review is to discuss how miRNAs become master regulators in breast tumorigenesis.

METHODS:

An integrative review of miRNAs and breast cancer literature from the last 5 years was done on PubMed. We summarize recent works showing that the defects on the biogenesis of miRNAs are associated with different breast cancer characteristics. Then, we show several examples that demonstrate the link between cellular processes regulated by miRNAs and the hallmarks of breast cancer. Finally, we examine the complexity in the regulation of these molecules as they are modulated by other non-coding RNAs and the clinical applications of miRNAs as they could serve as good diagnostic and classification tools.

CONCLUSION:

The information presented in this review is important to encourage new directed studies that consider microRNAs as a good tool to improve the diagnostic and treatment alternatives in breast cancer.

KEYWORDS:

Breast cancer; Cancer; Stem cells; miRNA

PMID:
29948402
DOI:
10.1007/s10549-018-4850-7
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center