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Trends Mol Med. 2018 Jul;24(7):615-629. doi: 10.1016/j.molmed.2018.05.007. Epub 2018 Jun 19.

Axon Regeneration: Antagonistic Signaling Pairs in Neuronal Polarization.

Author information

1
Department of Medicine, School of Medicine, University of Minnesota, 401 East River Parkway, Minneapolis, MN 55455, USA.
2
Department of Neurology, School of Medicine, Yale University, 300 George Street, New Haven, CT 06511, USA; Department of Pharmacology, School of Medicine, Yale University, 333 Cedar Street, New Haven, CT 06520, USA; Equal contribution. Electronic address: sourav.ghosh@yale.edu.
3
Department of Pharmacology, School of Medicine, Yale University, 333 Cedar Street, New Haven, CT 06520, USA; Department of Immunobiology, School of Medicine, Yale University, 300 Cedar Street, New Haven, CT 06520, USA; Equal contribution. Electronic address: carla.rothlin@yale.edu.

Abstract

Genome-wide screens, proteomics, and candidate-based approaches have identified numerous genes associated with neuronal regeneration following central nervous system (CNS) injury. Despite significant progress, functional recovery remains a challenge, even in model systems. Neuronal function depends on segregation of axonal versus dendritic domains. A key to functional recovery may lie in recapitulating the developmental signals that instruct axon specification and growth in adult neurons post-injury. Theoretically, binary activator-inhibitor elements operating as a Turing-like system within neurons can specify axonal versus dendritic domains and promote axon growth. We review here various molecules implicated in axon specification that function as signaling pairs driving neuronal polarization and axon growth.

PMID:
29934283
DOI:
10.1016/j.molmed.2018.05.007
[Indexed for MEDLINE]

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