Format

Send to

Choose Destination
Am J Physiol Heart Circ Physiol. 2018 Jun 15. doi: 10.1152/ajpheart.00188.2018. [Epub ahead of print]

BLOOD PRESSURE PREDICTS ENDOTHELIAL FUNCTION AND THE EFFECTS OF ETHINYL ESTRADIOL EXPOSURE IN YOUNG WOMEN.

Author information

1
John B. Pierce Laboratory.
2
Kinesiology and Physical Education, McGill University, Canada.
3
Environmental Health, Nara Women's University, Japan.
4
Yale School of Medicine, Department of Obstetrics, Gynecology and Reproductive and School of Public Health, The John B. Pierce Laboratory, United States.

Abstract

Hypertension, obesity, and endothelial function predict cardiovascular disease in women and these factors are interrelated. We hypothesized that hypertension and obesity are associated with endothelial dysfunction in young women, and that short-term ethinyl estradiol exposure mitigates this dysfunction. We examined flow-mediated dilation responses before and during 7 days of oral ethinyl estradiol (30 µg/day) in 19 women (25 ± 5, 18-35 yrs). We divided our sample into two groups based on two criteria: blood pressure and obesity. Women were divided into normal (NBP; n=7, mean arterial pressure range: 78-91 mmHg) and high blood pressure (HBP; n=9, mean arterial pressure range: 95-113 mmHg) groups. We also stratified our subjects by body composition (lean: 18-31%, n = 8; obese: 38-59%, n =9). We evaluated brachial flow-mediated dilation (FMD) following two distinct shear stress stimuli: occlusion-alone, and occlusion with ischemic handgrip exercise. Obesity was unrelated to both flow-mediated dilation responses. Prior to ethinyl estradiol administration, HBP had blunted ischemic exercise responses relative to NBP (8.0 {plus minus} 3.5% vs. 12.3 ± 3.2%, respectively; P=0.05). However, during ethinyl estradiol administration, ischemic exercise responses increased in HBP (12.8 ± 6.1%; P=0.04) but decreased in NBP (5.6 ± 2.4%, P=0.01). Standard flow-mediated dilation did not reveal differences between groups. In summary, 1) moderately high blood pressure predicted endothelial impairment; 2) ethinyl estradiol administration had divergent effects on FMD in normal vs. high blood pressure women; 3) enhanced flow-mediated dilation (ischemic handgrip exercise) revealed differences in endothelial function whereas standard flow-mediated dilation (occlusion-alone) did not.

KEYWORDS:

FMD; Flow-mediated vasodilation; blood pressure; ethinyl estradiol; obesity

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center