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Cureus. 2018 Mar 22;10(3):e2358. doi: 10.7759/cureus.2358.

Long-term Quality of Life in Survivors of Brain Metastases: A Roller Coaster of Perspective.

Author information

Department of Medicine, Frank H. Netter Md School of Medicine.
Neurology, Yale School of Medicine.
Medicine, Frank H. Netter Md School of Medicine.
Radiation Oncology, Yale School of Medicine.
Department of Neurosurgery, Yale School of Medicine.
Neurosurgery, Yale School of Medicine.


Longevity in cancer patients with brain metastases is increasingly being observed. This raises discussions about how best to maintain a good quality of life for these patients. Recent data suggest that post-treatment quality of life (QoL) can be maintained using new treatment options, but little data exist regarding the QoL in long-term survivors. This study of 19 patients surviving greater than two years from the initial treatment of brain metastases suggests that long-term QoL can be better than at the start of treatment and perhaps even better than normal, especially between three and five years post-treatment. This improved QoL seems mostly attributable to improved functional and social well-being and is possible as long as emotional and physical well-being are maintained within the normal range.


brain metastasis; breast cancer survivors; gamma knife radiosurgery; long-term toxicity; quality of life; radiation oncology; stereotactic radiosurgery

Conflict of interest statement

The authors have declared that no competing interests exist.

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