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Clin Exp Metastasis. 2018 Aug;35(5-6):431-442. doi: 10.1007/s10585-018-9898-6. Epub 2018 May 18.

Lymph node metastasis in melanoma: a debate on the significance of nodal metastases, conditional survival analysis and clinical trials.

Author information

1
The Angeles Clinic and Research Institute, 11800 Wilshire Blvd, Suite 300, Los Angeles, CA, USA. mfaries@theangelesclinic.org.
2
Cedars Sinai Medical Center, 11818 Wilshire Blvd, Suite 200, Los Angeles, CA, 90025, USA. mfaries@theangelesclinic.org.
3
Section of Surgical Oncology, Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.
4
Morsani School of Medicine, University of South Florida, Tampa, FL, USA.
5
Istituto Nazionale Tumori "Fondazione Pascale", Naples, Italy.

Abstract

While there is no doubt that regional lymph node metastases are an enormously important factor in melanoma staging and treatment, the biology behind this significance and its precise implications for treatment planning have been a leading controversy in melanoma and other solid tumors for over a century. Recent clinical data, including data from prospective randomized clinical trials have refined our understanding of the process of nodal metastases and the advantages and disadvantages of different clinical management strategies. This review presents two points of view in this debate and discusses the results of new data analyses as well as pivotal clinical trials informing the discussion.

KEYWORDS:

Clinical trial; Lymphatic mapping; Melanoma; Sentinel lymph node; Surgical oncology

PMID:
29777421
PMCID:
PMC6202130
DOI:
10.1007/s10585-018-9898-6
[Indexed for MEDLINE]
Free PMC Article

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