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FEBS J. 2018 May;285(9):1589-1592. doi: 10.1111/febs.14461. Epub 2018 Apr 22.

DUSPs, twists and turns in the Journey to Vascular Inflammation.

Author information

1
Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.
2
Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
3
Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, CT, USA.

Abstract

The MAPK phosphatase DUSP6/MKP-3 dephosphorylates ERK1 and 2 and negatively regulates ERK-dependent signaling. Hsu et al. now show that DUSP6/MKP-3 is required for the TNF-α-induced upregulation of the endothelial cell adhesion molecule-1 (ICAM-1) and neutrophil infiltration in endothelial cells, and interestingly, this positive role of DUSP6 on the inflammatory process is independent of ERK signaling.

PMID:
29682902
DOI:
10.1111/febs.14461

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