Send to

Choose Destination
J Am Geriatr Soc. 2018 Apr;66 Suppl 1:S4-S12. doi: 10.1111/jgs.15343.

State of the Science: Apathy As a Model for Investigating Behavioral and Psychological Symptoms in Dementia.

Author information

College of Nursing, Pennsylvania State University, University Park, Pennsylvania.
Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Program for Positive Aging, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.


Apathy is one of the most common and pervasive of the behavioral and psychological symptoms of dementia (BPSDs). Apathy has profound consequences for morbidity, mortality, and caregiver burden. Treatment of apathy has been hindered because of poor understanding of the mechanisms underlying this heterogeneous syndrome. Research has demonstrated that apathy is associated with disruption of the frontal-striatal system in individuals with neurodegenerative disease. As with other BPSDs, these neural mechanisms alone do not completely account for the syndrome; individual, caregiver, and environmental factors also contribute to apathy. In this article, we modify a current conceptual model of the factors contributing to BPSDs to examine determinants of apathy. This integrative model provides a more complete and theoretically informed understanding of apathy, allowing for greater insight into potential targets for research, intervention, and care. We end by proposing an agenda for moving the science of BPSDs in general, and apathy in particular, forward.


apathy; behavioral and psychological symptoms of dementia; goal-directed behavior

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center