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Curr Opin Hematol. 2018 May;25(3):227-236. doi: 10.1097/MOH.0000000000000424.

MicroRNAs in endothelial cell homeostasis and vascular disease.

Author information

1
Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Department of Pathology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, USA.

Abstract

PURPOSE OF REVIEW:

Since the first discovery of microRNAs (miRNAs) in 1993, the involvement of miRNAs in different aspects of vascular disease has emerged as an important research field. In this review, we summarize the fundamental roles of miRNAs in controlling endothelial cell functions and their implication with several aspects of vascular dysfunction.

RECENT FINDINGS:

MiRNAs have been found to be critical modulators of endothelial homeostasis. The dysregulation of miRNAs has been linked to endothelial dysfunction and the development and progression of vascular disease which and open new opportunities of using miRNAs as potential therapeutic targets for vascular disease.

SUMMARY:

Further determination of miRNA regulatory circuits and defining miRNAs-specific target genes remains key to future miRNA-based therapeutic applications toward vascular disease prevention. Many new and unanticipated roles of miRNAs in the control of endothelial functions will assist clinicians and researchers in developing potential therapeutic applications.

PMID:
29547400
PMCID:
PMC6175704
DOI:
10.1097/MOH.0000000000000424
[Indexed for MEDLINE]
Free PMC Article

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