Format

Send to

Choose Destination
Tuberculosis (Edinb). 2018 Jan;108:10-15. doi: 10.1016/j.tube.2017.10.001. Epub 2017 Oct 3.

Assessment of tuberculosis contact investigation in Shanghai, China: An 8-year cohort study.

Author information

1
Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China; Shenzhen Center for Chronic Disease Control, Shenzhen 518000, China.
2
Songjiang District Center for Disease Control and Prevention, Shanghai 201620, China.
3
Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.
4
Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
5
Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China.
6
Songjiang District Center for Disease Control and Prevention, Shanghai 201620, China. Electronic address: guoxiaoqin1102@163.com.
7
Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China; Shenzhen Center for Chronic Disease Control, Shenzhen 518000, China. Electronic address: qgao99@yahoo.com.

Abstract

BACKGROUND:

Tuberculosis (TB) contact investigation has been observed as a useful programmatic tool in active case finding. We collected data of contact cases to evaluate the effectiveness of TB contact investigation programme in Shanghai, China.

METHODS:

Since 2009, we screened and followed up the close contacts of bacteria-positive TB cases in Songjiang, Shanghai and calculated the incidence of TB in close contacts and confirmed the transmission by genotyping and sequencing.

RESULTS:

A total of 4584 close contacts of 1765 contagious TB index cases were followed up for an average of 4 years. About 62 contacts (333/100 000, 95% CI: 256-428) developed TB excluding 6 co-prevalent cases. The contact cases consisted 1.50% (39/2592) of all the bacteria-positive cases in population. Transmission links were confirmed in 60% (9/15) familial contacts and 22% (2/9) in non-familial contacts. Source cases come from more than close contacts and both index and contact cases created other secondary cases in community.

CONCLUSIONS:

Familial contacts are more likely to acquire TB from the index, indicating the priority of family members in TB contact investigation in China. However, most non-familial contacts were infected from sources in the community and contact cases attributed little to case finding in the TB-prevalent setting. Thus, active case finding should be strengthened in general population.

KEYWORDS:

Contact investigation; Transmission; Tuberculosis

PMID:
29523308
DOI:
10.1016/j.tube.2017.10.001

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center