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Pain Manag. 2018 Mar;8(2):85-94. doi: 10.2217/pmt-2017-0041. Epub 2018 Jan 30.

Qualities of Sore Throat Index (QuaSTI): measuring descriptors of sore throat in a randomized, placebo-controlled trial.

Author information

1
Schachtel Research Company Inc., Jupiter, FL 33477, USA.
2
Yale School of Public Health, New Haven, CT 06520-8034, USA.
3
Reckitt Benckiser Healthcare International Ltd, 103-105 Bath Road, Slough, Berkshire SL1 3UH, UK.
4
Reckitt Benckiser, Parsippany, NJ 07054-0225, USA.

Abstract

AIM:

Patients with pharyngitis often describe various sensory, affective and evaluative pain qualities. Using an 11-word/phrase index, the Qualities of Sore Throat Index (QuaSTI), we characterized throat symptoms and evaluated changes in a randomized controlled trial (NCT01986361).

MATERIALS & METHODS:

Patients received a single flurbiprofen 8.75 mg (n = 101) or placebo (n = 21) lozenge and rated throat soreness at baseline and regular intervals over 3 h, and the QuaSTI at baseline, 1, 2 and 3 h post-treatment.

RESULTS:

The QuaSTI distinguished active drug from placebo and detected clinically important (≥2-point) changes over 3 h. Mean change from baseline over 3 h was significantly greater for flurbiprofen (154%) than placebo (p < 0.05).

CONCLUSION:

The QuaSTI is a sensitive instrument for measuring therapeutic effects in patients with pharyngitis.

KEYWORDS:

flurbiprofen; pharyngitis; sore throat

PMID:
29381110
DOI:
10.2217/pmt-2017-0041

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