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Ann Intern Med. 2018 Mar 6;168(5):309-316. doi: 10.7326/M16-2011. Epub 2018 Jan 9.

Effect of Physical Activity on Frailty: Secondary Analysis of a Randomized Controlled Trial.

Author information

1
Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland, and Tufts University, Boston, Massachusetts (A.T.).
2
Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland (M.H.).
3
Wake Forest School of Medicine, Winston-Salem, North Carolina (F.H.).
4
Tufts University, Boston, Massachusetts (K.F.R., R.A.F.).
5
Pennington Biomedical Research Center, Baton Rouge, Louisiana (T.S.C.).
6
Yale School of Medicine, New Haven, Connecticut (T.M.G.).
7
Stanford University, School of Medicine, Stanford, California (A.C.K.).
8
Tufts University and Boston University School of Medicine, Boston, Massachusetts (C.K.L.).
9
University of Florida, Gainesville, Florida (T.M.M., M.P.).
10
Northwestern University, Feinberg School of Medicine, Chicago, Illinois (M.M.M.).
11
University of Pittsburgh, Pittsburgh, Pennsylvania (A.B.N.).
12
Wake Forest University and School of Medicine, Winston-Salem, North Carolina (W.J.R.).
13
University of Florida, Gainesville, Florida, and University of Maryland School of Medicine, Baltimore, Maryland (J.M.G.).

Abstract

Background:

Limited evidence suggests that physical activity may prevent frailty and associated negative outcomes in older adults. Definitive data from large long-term randomized trials are lacking.

Objective:

To determine whether a long-term, structured, moderate-intensity physical activity program is associated with a lower risk for frailty and whether frailty status alters the effect of physical activity on the reduction in major mobility disability (MMD) risk.

Design:

Multicenter, single-blind, randomized trial.

Setting:

8 centers in the United States.

Participants:

1635 community-dwelling adults, aged 70 to 89 years, with functional limitations.

Intervention:

A structured, moderate-intensity physical activity program incorporating aerobic, resistance, and flexibility activities or a health education program consisting of workshops and stretching exercises.

Measurements:

Frailty, as defined by the SOF (Study of Osteoporotic Fractures) index, at baseline and 6, 12, and 24 months, and MMD, defined as the inability to walk 400 m, for up to 3.5 years.

Results:

Over 24 months of follow-up, the risk for frailty (n = 1623) was not statistically significantly different in the physical activity versus the health education group (adjusted prevalence difference, -0.021 [95% CI, -0.049 to 0.007]). Among the 3 criteria of the SOF index, the physical activity intervention was associated with improvement in the inability to rise from a chair (adjusted prevalence difference, -0.050 [CI, -0.081 to -0.020]). Baseline frailty status did not modify the effect of physical activity on reducing incident MMD (P for interaction = 0.91).

Limitation:

Frailty status was neither an entry criterion nor a randomization stratum.

Conclusion:

A structured, moderate-intensity physical activity program was not associated with a reduced risk for frailty over 2 years among sedentary, community-dwelling older adults. The beneficial effect of physical activity on the incidence of MMD did not differ between frail and nonfrail participants.

Primary Funding Source:

National Institute on Aging, National Institutes of Health.

Summary for patients in

PMID:
29310138
PMCID:
PMC5898617
DOI:
10.7326/M16-2011
[Indexed for MEDLINE]
Free PMC Article

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