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Salud Publica Mex. 2017 Sep-Oct;59(5):540-547. doi: 10.21149/8527.

CYP1A1, CYP1B1, GSTM1 and GSTT1 genetic variants and breast cancer risk in Mexican women.

Author information

1
Instituto Nacional de Salud Pública. México.
2
Instituto Nacional de Medicina Genómica. México.
3
Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional. México.

Abstract

OBJECTIVE:

To evaluate if variants in the genes CYP1A1 (T3801C and A4889G), CYP1B1 (G119T), GSTM1 (indel) and GSTT1 (indel) are associated with breast cancer (BC) among Mexican women.

MATERIALS AND METHODS:

952 incident cases with histologically confirmed BC were matched by age (± 5 years) and zone of residence with 998 healthy population controls. Genetic variants in genes CYP1A1, CYP1B1, GSTM1 and GSTT1were genotyped by allelic discrimination and multiplex PCR. In a subsample of women, 105 markers for ancestry were determined.

RESULTS:

An increased BC risk, independent of other BC risk factors, was observed among carriers of CYP1B1 G119T genotype (T/T vs. G/G: OR=1.9; 95%CI 1.4-2.5).

CONCLUSION:

Our results support the existence of genetic susceptibility for BC conferred by CYP1B1 G119T variant among Mexican women.

PMID:
29267651
DOI:
10.21149/8527
[Indexed for MEDLINE]

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