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Diab Vasc Dis Res. 2018 Mar;15(2):158-161. doi: 10.1177/1479164117745260. Epub 2017 Dec 13.

SOS1 gene polymorphisms are associated with gestational diabetes mellitus in a Chinese population: Results from a nested case-control study in Taiyuan, China.

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1 Department of Epidemiology, College of Public Health, Shanxi Medical University, Taiyuan, China.
2 Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.
3 Department of Obstetrics, The First Affiliated Hospital, Shanxi Medical University, Taiyuan, China.
4 Department of Information, The First Affiliated Hospital, Shanxi Medical University, Taiyuan, China.
5 Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA.
6 Center for Disease Control and Prevention, Taiyuan Railway Administration, Taiyuan, China.
7 Department of Surgery, Yale School of Medicine, New Haven, CT, USA.


Gestational diabetes mellitus is a growing public health concern due to its large disease burden; however, the underlying pathophysiology remains unclear. Therefore, we examined the relationship between 107 single-nucleotide polymorphisms in insulin signalling pathway genes and gestational diabetes mellitus risk using a nested case-control study. The SOS1 rs7598922 GA and AA genotype were statistically significantly associated with reduced gestational diabetes mellitus risk ( ptrend = 0.0006) compared with GG genotype. At the gene level, SOS1 was statistically significantly associated with gestational diabetes mellitus risk after adjusting for multiple comparisons. Moreover, AGGA and GGGG haplotypes in SOS1 gene were associated with reduced risk of gestational diabetes mellitus. Our study provides evidence for an association between the SOS1 gene and risk of gestational diabetes mellitus; however, its role in the pathogenesis of gestational diabetes mellitus will need to be verified by further studies.


SOS1; Single-nucleotide polymorphism; gestational diabetes mellitus

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