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J Behav Med. 2018 Jun;41(3):374-384. doi: 10.1007/s10865-017-9905-4. Epub 2017 Dec 11.

Elevated inflammation in association with alcohol abuse among Blacks but not Whites: results from the MIDUS biomarker study.

Author information

1
Department of Social and Behavioral Sciences, Yale School of Public Health, 60 College Street, 403, New Haven, CT, 06510, USA. Yusuf.ransome@yale.edu.
2
Department of Epidemiology and Biostatistics, University of Maryland School of Public Health, 4200 Valley Drive, College Park, MD, 20742, USA.
3
Center for Molecular Medicine, Karolinska Institute, Solna, Sweden.
4
Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 751 24, Uppsala, Sweden.
5
Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.

Abstract

Some studies document racial disparities in self-reported health associated with alcohol use and abuse. However, few studies examined biomarkers that underlie the onset of alcohol-related chronic diseases. We investigated whether the association between alcohol abuse and five biomarkers of inflammation (CRP, IL-6, fibrinogen, E-selectin, sICAM-1) vary between Black and White Americans aged 35 to 84 (n = 1173) from the Midlife in the United States Biomarker Study. Multivariable Ordinary Least Squares regressions were used to assess Black-White differences in the association between alcohol abuse and the biomarkers. Race moderated the association between alcohol abuse and CRP (b = 0.56, SE = 0.28, p = 0.048), IL-6 (b = 0.65, SE = 0.22, p = 0.004), and a composite inflammation score (b = 0.014, SE = 0.07, p = 0.041). These findings potentially shed light for why alcohol has a stronger negative association with poorer health for Blacks compared to Whites. Analysis should be replicated in larger prospective cohorts.

KEYWORDS:

Alcohol abuse; Biological markers; Chronic disease; Inflammation; MIDUS; Race/ethnicity

PMID:
29230616
PMCID:
PMC5924626
[Available on 2019-06-01]
DOI:
10.1007/s10865-017-9905-4

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