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Oncotarget. 2017 Jul 27;8(54):91876-91886. doi: 10.18632/oncotarget.19621. eCollection 2017 Nov 3.

Functional polymorphisms in pre-miR146a and pre-miR499 are associated with systemic lupus erythematosus but not with rheumatoid arthritis or Graves' disease in Mexican patients.

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Endocrine and Metabolic Disease Unit Research, Hospital Juarez of Mexico, Mexico City, Mexico.
Superior School of Medicine Postgraduate Program, National Polytechnic Institute, Mexico City, Mexico.
Rheumatology Department, Hospital Juarez of Mexico, Mexico City, Mexico.
Oncology Department, National Institute of Genomic Medicine, Mexico City, Mexico.
Immunology Department, National Institute of Cardiology, Mexico City, Mexico.
Hematology Laboratory, Regional Research Center, Autonomous University of Yucatan, Yucatan, Mexico.
Research Direction, Hospital Juarez of Mexico, Mexico City, Mexico.
Endocrine Department, Hospital Juarez of Mexico, Mexico City, Mexico.
Rheumatology Department, Regional Hospital General (ISSSTE), Health Service Yucatan, Yucatan, Mexico.
Direction of Chronic Infections and Cancer, Research Center in Infection Diseases, National Institute of Public Health, Cuernavaca, México.
Multidisciplinary Academic Division of Comalcalco, Juarez Autonomous University of Tabasco, Comalcalco, Mexico.


Recently, different microRNA (miRNA) gene polymorphisms have been evaluated in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Graves' disease (GD). In the present study, we examined three single-nucleotide polymorphisms (SNPs) located in the pre-miR-146a (rs2910164G/C), pre-miR-196a-2 (rs11614913C/T), and pre-miR-499 (rs3746444A/G) genes. Our study population included 900 Mexican patients with RA, SLE, or GD, as well as 486 healthy control individuals with no family history of inflammatory or autoimmune diseases. Genotyping was performed using TaqMan probes and a 5' exonuclease assay. None of the investigated SNPs were associated with RA or GD susceptibility under any genetic model (co-dominant, recessive, or dominant). Genotype and allele frequencies of the miR-196a-2 rs11614913C/T polymorphism were similar between SLE cases and controls. In contrast, the miR-146a rs2910164G/C and miR-499 rs3746444A/G polymorphisms were associated with SLE susceptibility. These SNPs were not associated with lupus nephritis (LN). Our results suggest that polymorphisms in miR-146a, miR-196a-2, and miR-499 are not associated with RA or GD susceptibility. This is the first report documenting that the miR-146a rs2910164G/C and miR-499 rs3746444 polymorphisms are associated with SLE susceptibility but not with LN.


Graves’ disease; microRNA gene; rheumatoid arthritis; susceptibility; systemic lupus erythematosus

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest.

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