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Receptors Clin Investig. 2016;3(1). pii: e1169. doi: 10.14800/rci.1169. Epub 2016 Feb 1.

Calcium signaling and transcription: elongation, DoGs, and eRNAs.

Author information

1
Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.

Abstract

The calcium ion (Ca2+) is a key intracellular signaling molecule with far-reaching effects on many cellular processes. One of the most important such Ca2+ regulated processes is transcription. A body of literature describes the effect of Ca2+ signaling on transcription initiation as occurring mainly through activation of gene-specific transcription factors by Ca2+-induced signaling cascades. However, the reach of Ca2+ extends far beyond the first step of transcription. In fact, Ca2+ can regulate all phases of transcription, with additional effects on transcription-associated events such as alternative splicing. Importantly, Ca2+ signaling mediates reduced transcription termination in response to certain stress conditions. This reduction allows readthrough transcription, generating a highly inducible and diverse class of downstream of gene containing transcripts (DoGs) that we have recently described.

KEYWORDS:

Ca2+ signaling; DoGs; readthrough transcription; transcription regulation

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