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J Acquir Immune Defic Syndr. 2018 Mar 1;77(3):337-344. doi: 10.1097/QAI.0000000000001595.

HIV and Age Do Not Synergistically Affect Age-Related T-Cell Markers.

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Department of Medicine, Section of Infectious Diseases, Yale University, School of Medicine, New Haven, CT.
Department of Medicine, Division of Experimental Medicine, University of California, San Francisco, CA.
Currently, Division of Infectious Disease, University of Colorado, Denver, CO.
Center for Analytical Sciences, Yale University School of Public Health, New Haven, CT.
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Division of Infectious Diseases, Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, CA.
Center for Population Health Sciences, Stanford University School of Medicine, Stanford, CA.



Despite major progress in controlling HIV disease through antiretroviral therapy, changes in immune phenotype and function persist in individuals with chronic HIV, raising questions about accelerated aging of the immune system.


We conducted a cross-sectional study (2005-2007) of HIV-infected (n = 111) and uninfected (n = 114) men from the Veterans Aging Cohort Study. All HIV-infected subjects were on antiretroviral therapy with VL <400 copies/mL for at least 3 years. T-cell markers were examined using flow cytometry. We evaluated the impact of HIV serostatus and age on T-cell phenotypes (expressed as percentages of the total CD4 and CD8 T-cell population) using multivariate linear regression, adjusted for smoking, alcohol, and race/ethnicity. We tested for interactions between HIV and age by including interaction terms.


Among both HIV-infected and uninfected subjects, increasing age was associated with a decreased proportion of naive CD4 T cells (P = 0.014) and CD8 T cells (P < 0.0001). Both HIV infection and increasing age were associated with higher proportions of effector memory CD4 T cells (P < 0.0001 for HIV; P = 0.04 for age) and CD8 T cells (P = 0.0001 for HIV; P = 0.0004 for age). HIV infection, but not age, was associated with a higher proportion of activated CD8 T cells (P < 0.0001). For all T-cell subsets tested, there were no significant interactions between HIV infection and age.


Age and HIV status independently altered the immune system, but we found no conclusive evidence that HIV infection and advancing age synergistically result in accelerated changes in age-associated T-cell markers among virally suppressed individuals.

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