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J Nat Prod. 2017 Dec 22;80(12):3103-3111. doi: 10.1021/acs.jnatprod.6b01127. Epub 2017 Nov 15.

Cornusides A-O, Bioactive Iridoid Glucoside Dimers from the Fruit of Cornus officinalis.

Author information

1
School of Life Sciences & School of Chinese Medicine Sciences, Beijing University of Chinese Medicine , Beijing 100029, People's Republic of China.
2
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital , Beijing 100029, People's Republic of China.
3
Department of Pharmacy, China-Japan Friendship Hospital , Beijing 100029, People's Republic of China.
4
Department of Pharmacology, Yale University School of Medicine , New Haven, Connecticut 06520, United States.
5
Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University , Beijing 100038, People's Republic of China.

Abstract

Fifteen new and rare iridoid glucoside dimers, cornusides A-O (1-15), and 10 known iridoid glucosides (16-25) were isolated from the fruit of Cornus officinalis. These new chemical structures were established through spectroscopic analysis (UV, IR, HRESIMS, 1D and 2D NMR). Compounds 1-25 were tested for their inhibitory activities by measuring IL-6-induced STAT3 promoter activity in HepG2 cells, and 3, 12, 17, 22, and 23 showed inhibitory effects, with IC50 values of 11.9, 12.2, 14.0, 7.0, and 6.9 μM, respectively.

PMID:
29140705
DOI:
10.1021/acs.jnatprod.6b01127
[Indexed for MEDLINE]

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