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Am J Trop Med Hyg. 2018 Feb;98(2):410-419. doi: 10.4269/ajtmh.17-0350. Epub 2017 Aug 31.

Characterization of Three New Insect-Specific Flaviviruses: Their Relationship to the Mosquito-Borne Flavivirus Pathogens.

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Department of Pathology and Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas.
Programa de Estudio y Control de Enfermedades Tropicales - PECET - SIU - Sede de Investigacion Universitaria - Universidad de Antioquia, Medellin, Colombia.
Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, Para, Brazil.
Postgraduate Program in Virology, Evandro Chagas Institute, Ministry of Health, Ananindeua, Para, Brazil.
Department of Biology, New Mexico State University, Las Cruces, New Mexico.
School of Public Health, University of Washington, Seattle, Washington.
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut.
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas.
Border Biomedical Research Center, University of Texas at El Paso, El Paso, Texas.
U.S. Naval Medical Research Unit-6, Callao, Peru.
Institute of Health and Community Medicine, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia.
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut.


Three novel insect-specific flaviviruses, isolated from mosquitoes collected in Peru, Malaysia (Sarawak), and the United States, are characterized. The new viruses, designated La Tina, Kampung Karu, and Long Pine Key, respectively, are antigenically and phylogenetically more similar to the mosquito-borne flavivirus pathogens, than to the classical insect-specific viruses like cell fusing agent and Culex flavivirus. The potential implications of this relationship and the possible uses of these and other arbovirus-related insect-specific flaviviruses are reviewed.

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