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CNS Oncol. 2017 Oct;6(4):281-285. doi: 10.2217/cns-2017-0004. Epub 2017 Oct 9.

Leiomyosarcoma of the infratemporal fossa with perineurial spread along the right mandibular nerve: a case report.

Author information

1
Department of Neurology, Yale School of Medicine, New Haven, CT 06510, USA.
2
Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
3
Department of Surgery, Otolaryngology, Yale School of Medicine, New Haven, CT 06520, USA.
4
Department of Neurosurgery, Yale School of Medicine, New Haven, CT 06520, USA.

Abstract

Leiomyosarcomas are malignant tumors displaying strong smooth muscle differentiation. They can often develop within the GI tract and myometrium, but are particularly rare in the head and neck. Perineurial spread of head and neck cancer is observed in patients with neoplasms of the skin (squamous cell carcinoma, melanoma) or skin appendages (adenoid cystic carcinoma). We report the case of a woman who presented with diplopia and headaches. MRI showed an infratemporal mass lesion and faint enhancement tracking along the mandibular nerve into the wall of the right cavernous sinus. A nerve biopsy revealed leiomyosarcoma. We review the medical literature to provide further insight into the diagnosis and management of this tumor and its peculiar pattern of spread. A similar case was unidentifiable in the literature.

KEYWORDS:

cancer; leiomysarcoma; perineurial

PMID:
28990793
PMCID:
PMC6004886
DOI:
10.2217/cns-2017-0004
[Indexed for MEDLINE]
Free PMC Article

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