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Trends Endocrinol Metab. 2017 Nov;28(11):759-760. doi: 10.1016/j.tem.2017.09.004. Epub 2017 Sep 27.

A Tale of Two Elabela Null Mice.

Author information

1
Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA.
2
Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA. Electronic address: hyung.chun@yale.edu.

Abstract

Elabela (ELA), the second peptide ligand for the apelin receptor, APLNR, was previously found in lower vertebrates to be crucial for endoderm and cardiac development. Two new studies report on the phenotypes of Ela null mice, ranging from defective embryogenesis to preeclampsia, providing new insights and raising greater intrigue on this cardiometabolic pathway.

KEYWORDS:

APLNR signaling; GPCR; embryo development; preeclampsia

PMID:
28964631
PMCID:
PMC5673578
DOI:
10.1016/j.tem.2017.09.004
[Indexed for MEDLINE]
Free PMC Article

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