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Hum Brain Mapp. 2017 Nov;38(11):5421-5439. doi: 10.1002/hbm.23731. Epub 2017 Jul 26.

Mothers with substance addictions show reduced reward responses when viewing their own infant's face.

Author information

1
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, United States.
2
Department of Pediatrics and Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, United States.
3
Center for Reproductive Psychiatry, Pavilion for Women, Texas Children's Hospital, Houston, Texas, United States.
4
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
5
Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut, United States.
6
Departments of Psychiatry and Neuroscience and the National Center on Addiction and Substance Abuse (CASAColumbia), Yale University School of Medicine, New Haven, Connecticut, United States.
7
Connecticut Mental Health Center, New Haven, Connecticut, United States.
8
Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States.

Abstract

Maternal addiction constitutes a major public health problem affecting children, with high rates of abuse, neglect, and foster care placement. However, little is known about the ways in which substance addiction alters brain function related to maternal behavior. Prior studies have shown that infant face cues activate similar dopamine-associated brain reward regions to substances of abuse. Here, we report on a functional MRI study documenting that mothers with addictions demonstrate reduced activation of reward regions when shown reward-related cues of their own infants. Thirty-six mothers receiving inpatient treatment for substance addiction were scanned at 6 months postpartum, while viewing happy and sad face images of their own infant compared to those of a matched unknown infant. When viewing happy face images of their own infant, mothers with addictions showed a striking pattern of decreased activation in dopamine- and oxytocin-innervated brain regions, including the hypothalamus, ventral striatum, and ventromedial prefrontal cortex-regions in which increased activation has previously been observed in mothers without addictions. Our results are the first to demonstrate that mothers with addictions show reduced activation in key reward regions of the brain in response to their own infant's face cues. Hum Brain Mapp 38:5421-5439, 2017. © 2017 Wiley Periodicals, Inc.

KEYWORDS:

addiction; dopamine; infant; maternal; oxytocin; reward

PMID:
28746733
DOI:
10.1002/hbm.23731
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