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Dev Cell. 2017 Jul 24;42(2):107-108. doi: 10.1016/j.devcel.2017.07.005.

How Primordial Germ Cells Destroy Somatic Signals.

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Departments of Genetics, Cell Biology and Molecular, Cellular & Developmental Biology, Yale University, New Haven, CT 06520, USA. Electronic address:


The Germ Cell-Less (GCL) protein is a key regulator of primordial germ cell (PGC) formation in Drosophila embryos. Reporting in this issue of Developmental Cell, Pae et al. (2017) show that GCL blocks somatic cell fate by specifically destroying the Torso Receptor Tyrosine Kinase.

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