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PLoS Pathog. 2017 Jul 24;13(7):e1006532. doi: 10.1371/journal.ppat.1006532. eCollection 2017 Jul.

Salmonella enterica serovar-specific transcriptional reprogramming of infected cells.

Author information

1
Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America.

Abstract

Despite their high degree of genomic similarity, different Salmonella enterica serovars are often associated with very different clinical presentations. In humans, for example, the typhoidal S. enterica serovar Typhi causes typhoid fever, a life-threatening systemic disease. In contrast, the non-typhoidal S. enterica serovar Typhimurium causes self-limiting gastroenteritis. The molecular bases for these different clinical presentations are incompletely understood. The ability to re-program gene expression in host cells is an essential virulence factor for typhoidal and non-typhoidal S. enterica serovars. Here, we have compared the transcriptional profile of cultured epithelial cells infected with S. Typhimurium or S. Typhi. We found that both serovars stimulated distinct transcriptional responses in infected cells that are associated with the stimulation of specific signal transduction pathways. These specific responses were associated with the presence of a distinct repertoire of type III secretion effector proteins. These observations provide major insight into the molecular bases for potential differences in the pathogenic mechanisms of typhoidal and non-typhoidal S. enterica serovars.

PMID:
28742135
PMCID:
PMC5549772
DOI:
10.1371/journal.ppat.1006532
[Indexed for MEDLINE]
Free PMC Article

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