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Curr Opin Struct Biol. 2017 Jul 18;47:77-87. doi: 10.1016/j.sbi.2017.06.010. [Epub ahead of print]

Structural biology of telomerase and its interaction at telomeres.

Author information

1
Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095-1569, USA.
2
Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095-1569, USA. Electronic address: feigon@mbi.ucla.edu.

Abstract

Telomerase is an RNP that synthesizes the 3' ends of linear chromosomes and is an important regulator of telomere length. It contains a single long non-coding telomerase RNA (TER), telomerase reverse transcriptase (TERT), and other proteins that vary among organisms. Recent progress in structural biology of telomerase includes reports of the first cryo-electron microscopy structure of telomerase, from Tetrahymena, new crystal structures of TERT domains, telomerase RNA structures and models, and identification in Tetrahymena telomerase holoenzyme of human homologues of telomere-associated proteins that have provided a more unified view of telomerase interaction at telomeres as well as insights into the role of telomerase RNA in activity and assembly.

PMID:
28732250
PMCID:
PMC5564310
[Available on 2019-01-18]
DOI:
10.1016/j.sbi.2017.06.010
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