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Pulm Circ. 2017 Jul-Sep;7(3):730-733. doi: 10.1177/2045893217724141. Epub 2017 Jul 31.

Complexity of macrophage migration inhibitory factor (MIF) and other angiogenic biomarkers profiling in pulmonary arterial hypertension.

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1 Yale University School of Medicine, Section of Pulmonary, Critical Care, & Sleep Medicine, New Haven, CT, USA.
2 Cleveland Clinic, Department of Pulmonary and Critical Care, Cleveland, OH, USA.
3 United Therapeutics Corporation, Research Triangle Park, NC, USA.
4 Yale University School of Medicine, Section of Rheumatology, New Haven, CT, USA.


Macrophage migration inhibitory factor (MIF) and 22‚ÄČa priori selected biomarkers were measured from pulmonary arterial hypertension (PAH) patients. Significant positive correlations were found between MIF and several angiogenic factors suggesting a possible MIF regulation role in PAH angiogenesis and pathobiology, but simultaneously highlighting the biomarkers profiling complexity in PAH.


angiogenesis; biomarker; pulmonary arterial hypertension

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