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Biochem Pharmacol. 2017 Sep 1;139:94-104. doi: 10.1016/j.bcp.2017.06.123. Epub 2017 Jun 19.

Major achievements of evidence-based traditional Chinese medicine in treating major diseases.

Author information

1
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing; Graduate Institute of Health-Industry Technology, Research Center for Food and Cosmetic Safety, and Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan City; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung.
2
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing.
3
Natural Products Laboratory, Institute of Biology, Leiden University, Leiden.
4
Department of Pharmacology, Yale University School of Medicine, New Haven, CT.
5
Graduate Institute of Health-Industry Technology, Research Center for Food and Cosmetic Safety, and Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan City.
6
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing. Electronic address: slchen@icmm.ac.cn.

Abstract

A long history of use and extensive documentation of the clinical practices of traditional Chinese medicine resulted in a considerable number of classical preparations, which are still widely used. This heritage of our ancestors provides a unique resource for drug discovery. Already, a number of important drugs have been developed from traditional medicines, which in fact form the core of Western pharmacotherapy. Therefore, this article discusses the differences in drug development between traditional medicine and Western medicine. Moreover, the article uses the discovery of artemisinin as an example that illustrates the "bedside-bench-bedside" approach to drug discovery to explain that the middle way for drug development is to take advantage of the best features of these two distinct systems and compensate for certain weaknesses in each. This article also summarizes evidence-based traditional medicines and discusses quality control and quality assessment, the crucial steps in botanical drug development. Herbgenomics may provide effective tools to clarify the molecular mechanism of traditional medicines in the botanical drug development. The totality-of-the-evidence approach used by the U.S. Food and Drug Administration for botanical products provides the directions on how to perform quality control from the field throughout the entire production process.

KEYWORDS:

Artemisinin; Drug development; Evidence-based traditional medicines; Quality control; Traditional Chinese medicine; Western medicine

PMID:
28636884
DOI:
10.1016/j.bcp.2017.06.123
[Indexed for MEDLINE]

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