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Antioxidants (Basel). 2017 Jun 8;6(2). pii: E42. doi: 10.3390/antiox6020042.

The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk.

Author information

1
Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China. chen_cf547@126.com.
2
Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China. lilihaha900107@163.com.
3
Department of Pathology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520, USA. huanjiao.zhou@yale.edu.
4
Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China. wang.min@yale.edu.
5
Department of Pathology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520, USA. wang.min@yale.edu.

Abstract

The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) family is the major source of reactive oxygen species (ROS) in the vascular system. In this family, NOX4, a constitutive active form of NOXs, plays an important role in angiogenesis. Thioredoxin 2 (TRX2) is a key mitochondrial redox protein that maintains normal protein function and also provides electrons to peroxiredoxin 3 (PRX3) to scavenge H₂O₂ in mitochondria. Angiogenesis, a process of new blood vessel formation, is involved in a variety of physiological processes and pathological conditions. It seems to be paradoxical for ROS-producing NOX4 and ROS-scavenging TRX2 to have a similar role in promoting angiogenesis. In this review, we will focus on data supporting the role of NOX4 and TRX2 in angiogenesis and their cross-talks and discuss how ROS can positively or negatively regulate angiogenesis, depending on their species, levels and locations. NOX4 and TRX2-mediated ROS signaling could be promising targets for the treatment of angiogenesis-related diseases.

KEYWORDS:

NOX4; ROS; TRX2; angiogenesis

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