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Sci Rep. 2017 Jun 7;7(1):2978. doi: 10.1038/s41598-017-02596-1.

White matter microstructural changes are related to cognitive dysfunction in essential tremor.

Author information

1
Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain. jbenitol67@gmail.com.
2
Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. jbenitol67@gmail.com.
3
Department of Medicine, Faculty of Medicine, Complutense University, Madrid, Spain. jbenitol67@gmail.com.
4
Neuroimaging Laboratory, Center for Biomedical Technology, Rey Juan Carlos University, Móstoles, Madrid, Spain.
5
Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, USA.
6
Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT, USA.
7
Center for Neuroepidemiology and Clinical Neurological Research, Yale School of Medicine, Yale University, New Haven, CT, USA.
8
Department of Radiology, Hospital Ruber International, Madrid, Spain.
9
Department of Medicine, Faculty of Medicine, Complutense University, Madrid, Spain.
10
Clinical Research Unit, University Hospital, "12 de Octubre", Madrid, Spain.
11
Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain.
12
Faculty of Biosanitary Sciences, Francisco de Vitoria University, Pozuelo de Alarcón, Madrid, Spain.
13
Brain Damage Service, Hospital Beata Maria Ana, Madrid, Spain.

Abstract

Diffusion tensor imaging (DTI) studies have detected white matter microstructural changes in essential tremor (ET). However, it is still unclear whether these changes are related to cognitive deficits, which have been described in ET patients. DTI-derived fractional anisotropy, mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity measures were compared between 23 ET patients and 23 age-, gender-, and education-matched healthy individuals, using whole-brain tract-based spatial statistics. Correlations of white matter changes with scores obtained from a detailed neuropsychological assessment were subsequently examined. ET patients demonstrated increases in MD in the bilateral posterior corona radiata, bilateral superior longitudinal fasciculus, bilateral fornix (cres)/stria terminalis, genu and splenium of the corpus callosum, bilateral anterior and posterior limbs of internal capsule, bilateral retrolenticular region part of internal capsule, and left posterior thalamic radiation. Except for the genu of the corpus callosum, an increase in AD values was also found in these same tracts. Furthermore, increased MD and AD values in different white matter areas was negatively correlated with performance on language and verbal memory and positively with visuospatial ability. These correlations suggest that white matter changes might be involved in the pathogenesis of cognitive deficits in ET.

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