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Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00522-17. doi: 10.1128/AAC.00522-17. Print 2017 Aug.

Upregulation of Apoptosis Pathway Genes in Peripheral Blood Mononuclear Cells of HIV-Infected Individuals with Antiretroviral Therapy-Associated Mitochondrial Toxicity.

Author information

1
Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA.
2
Ragon Institute and Harvard Medical School, Cambridge, Massachusetts, USA.
3
Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA elijah.paintsil@yale.edu.
4
Department of Pharmacology, Yale School of Medicine, New Haven, Connecticut, USA.
5
Department of Epidemiology & Public Health, Yale School of Medicine, New Haven, Connecticut, USA.

Abstract

A case-control study of the effect of antiretroviral therapy (ART) on apoptosis pathway genes comprising 16 cases (HIV infected with mitochondrial toxicity) and 16 controls (HIV uninfected) was conducted. A total of 26 of 84 genes of the apoptosis pathway were differentially expressed. Two of the upregulated genes, DFFA and TNFRSF1A, classified 75% of study participants correctly as either a case or control. Thus, apoptosis may be in the causal pathway of ART-associated mitochondrial toxicity. These two genes could be markers for detecting and monitoring ART-induced mitochondrial toxicity.

KEYWORDS:

antiretroviral therapy; apoptosis; biomarker; mitochondrial toxicity

PMID:
28584150
PMCID:
PMC5527626
DOI:
10.1128/AAC.00522-17
[Indexed for MEDLINE]
Free PMC Article

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