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PET Clin. 2017 Jul;12(3):329-350. doi: 10.1016/j.cpet.2017.03.001. Epub 2017 May 2.

PET Imaging for Early Detection of Alzheimer's Disease: From Pathologic to Physiologic Biomarkers.

Author information

1
PET Center, Huanshan Hospital, Fudan University, No. 518, East Wuzhong Road, Xuhui District, Shanghai 200235, China.
2
Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, No. 19, Xinjiekouwai Street, Beijing 10075, China.
3
Department of Radiology and Biomedical Imaging, PET Center, Yale University School of Medicine, PO Box 208048, New Haven, CT 06520-8048, USA.
4
Department of Radiology and Biomedical Imaging, PET Center, Yale University School of Medicine, PO Box 208048, New Haven, CT 06520-8048, USA. Electronic address: henry.huang@yale.edu.

Abstract

This article describes the application of various PET imaging agents in the investigation and diagnosis of Alzheimer's disease (AD), including radiotracers for pathologic biomarkers of AD such as β-amyloid deposits and tau protein aggregates, and the neuroinflammation biomarker 18 kDa translocator protein, as well as physiologic biomarkers, such as cholinergic receptors, glucose metabolism, and the synaptic density biomarker synaptic vesicle glycoprotein 2A. Potential of these biomarkers for early AD diagnosis is also assessed.

KEYWORDS:

Alzheimer's disease; Beta-amyloid; Cholinergic; Inflammation; PET imaging; SV2A; Synaptic density; Tau protein

PMID:
28576171
DOI:
10.1016/j.cpet.2017.03.001
[Indexed for MEDLINE]

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