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Antioxid Redox Signal. 2018 Mar 20;28(9):773-796. doi: 10.1089/ars.2017.7175. Epub 2017 Jun 30.

The Role of MicroRNAs in Environmental Risk Factors, Noise-Induced Hearing Loss, and Mental Stress.

Author information

1
1 Department of Cell Biology and Immunology, Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM) , Madrid, Spain .
2
2 Department of Environmental and Occupational Health Sciences, University of Washington , Seattle, Washington.
3
3 Instituto Madrileño de Estudios Avanzados-Alimentación (IMDEA-Food) , Madrid, Spain .
4
4 Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University , Portland, Oregon.
5
5 Department of Comparative Medicine, Yale University Medical School , New Haven, Connecticut.

Abstract

SIGNIFICANCE:

MicroRNAs (miRNAs) are important regulators of gene expression and define part of the epigenetic signature. Their influence on every realm of biomedicine is established and progressively increasing. The impact of environment on human health is enormous. Among environmental risk factors impinging on quality of life are those of chemical nature (toxic chemicals, heavy metals, pollutants, and pesticides) as well as those related to everyday life such as exposure to noise or mental and psychosocial stress. Recent Advances: This review elaborates on the relationship between miRNAs and these environmental risk factors.

CRITICAL ISSUES:

The most relevant facts underlying the role of miRNAs in the response to these environmental stressors, including redox regulatory changes and oxidative stress, are highlighted and discussed. In the cases wherein miRNA mutations are relevant for this response, the pertinent literature is also reviewed.

FUTURE DIRECTIONS:

We conclude that, even though in some cases important advances have been made regarding close correlations between specific miRNAs and biological responses to environmental risk factors, a need for prospective large-cohort studies is likely necessary to establish causative roles. Antioxid. Redox Signal. 28, 773-796.

KEYWORDS:

air pollution; deafness; environmental chemicals; hearing loss; heavy metals; mental stress; neuropsychiatric disorders; noise exposure; pesticides

PMID:
28562070
PMCID:
PMC5911706
DOI:
10.1089/ars.2017.7175
[Indexed for MEDLINE]
Free PMC Article

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