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Am J Med Genet B Neuropsychiatr Genet. 2017 Oct;174(7):683-690. doi: 10.1002/ajmg.b.32551. Epub 2017 May 29.

A genome-wide quantitative trait locus (QTL) linkage scan of NEO personality factors in Latino families segregating bipolar disorder.

Author information

Center of Excellence for Neurosciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas.
Department of Psychiatry, School of Medicine, Pusan National University, Busan, South Korea.
Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Unit on Statistical Genomics, National Institute of Mental Health, Bethesda, Maryland.
Los Angeles Biomedical Research Center at Harbor, University of California Los Angeles Medical Center, Torrance, California.
Centro Internacional de Trastornos Afectivos y de la Conducta Adictiva, Guatemala, Guatemala.
Centro de Investigacion en Biologia Celular y Molecular y Escuela de Biologia, Universidad de Costa Rica, San Jose, Costa Rica.
Instituto de Informacion e InvestigaciónenSalud Mental AC, Monterrey, Nuevo Leon, Mexico.
Department of Psychiatry, University Hospital, Autonomous University of Nuevo Leon, Mexico.
Grupo de Estudios Medicos y Familiares Carracci, S.C., Mexico, D.F., Mexico.
Instituto Nacional de Medicina Genomica, Mexico, D.F., Mexico.
Department of Psychiatry, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas.


Personality traits have been suggested as potential endophenotypes for Bipolar Disorder (BP), as they can be quantitatively measured and show correlations with BP. The present study utilized data from 2,745 individuals from 686 extended pedigrees originally ascertained for having multiplex cases of BP (963 cases of BPI or schizoaffective BP). Subjects were assessed with the NEO Personality Inventory, Revised (NEO PI-R) and genotyped using the Illumina HumanLinkage-24 Bead Chip, with an average genetic coverage of 0.67 cM. Two point linkage scores were calculated for each trait as a quantitative variable using SOLAR (Sequential Oligogenic Linkage Analysis Routines). Suggestive evidence for linkage was found for neuroticism at 1q32.1 (LOD = 2.52), 6q23.3 (2.32), 16p12 (2.79), extraversion at 4p15.3 (2.33), agreeableness at 4q31.1 (2.37), 5q34 (2.80), 7q31.1 (2.56), 16q22 (2.52), and conscientiousness at 4q31.1 (2.50). Each of the above traits have been shown to be correlated with the broad BP phenotype in this same sample. In addition, for the trait of openness, we found significant evidence of linkage to chromosome 3p24.3 (rs336610, LOD = 4.75) and suggestive evidence at 1q43 (2.74), 5q35.1 (3.03), 11q14.3 (2.61), 11q21 (2.30), and 19q13.1 (2.52). These findings support previous linkage findings of the openness trait to chromosome 19q13 and the agreeableness trait to 4q31 and identify a number of new loci for personality endophenotypes related to bipolar disorder.


Latino; NEO; bipolar disorder; genome-wide; linkage studies; personality

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