Functional RNA structures throughout the Hepatitis C Virus genome

Rebecca L Adams; Nathan Pirakitikulr; Anna Marie Pyle

doi:10.1016/j.coviro.2017.04.007

Functional RNA structures throughout the Hepatitis C Virus genome

Curr Opin Virol. 2017 Jun:24:79-86. doi: 10.1016/j.coviro.2017.04.007. Epub 2017 May 13.

Authors

Rebecca L Adams¹, Nathan Pirakitikulr¹, Anna Marie Pyle²

Affiliations

¹ Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.
² Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA; Department of Chemistry, Yale University, New Haven, CT 06511, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address: anna.pyle@yale.edu.

Abstract

The single-stranded Hepatitis C Virus (HCV) genome adopts a set of elaborate RNA structures that are involved in every stage of the viral lifecycle. Recent advances in chemical probing, sequencing, and structural biology have facilitated analysis of RNA folding on a genome-wide scale, revealing novel structures and networks of interactions. These studies have underscored the active role played by RNA in every function of HCV and they open the door to new types of RNA-targeted therapeutics.

Publication types

Review

MeSH terms

3' Untranslated Regions
Animals
Genome, Viral*
Hepacivirus / genetics*
Hepacivirus / physiology
Hepatitis C / therapy
Hepatitis C / virology
Humans
Internal Ribosome Entry Sites
Mice
Nucleic Acid Conformation
Open Reading Frames
RNA, Viral / chemistry*
RNA, Viral / metabolism*
Viral Proteins / genetics
Viral Proteins / metabolism
Virus Replication

Substances

3' Untranslated Regions
Internal Ribosome Entry Sites
RNA, Viral
Viral Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding