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Magn Reson Med. 2018 Feb;79(2):628-635. doi: 10.1002/mrm.26751. Epub 2017 May 12.

In vivo proton observed carbon edited (POCE) 13 C magnetic resonance spectroscopy of the rat brain using a volumetric transmitter and receive-only surface coil on the proton channel.

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Department of Biomedical Engineering, McGill University, Montreal, QC, Canada.
Brain Imaging Centre, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, QC, Canada.
Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA.
Department of Psychology, Faculty of Arts, McGill University, Montreal, QC, Canada.



In vivo carbon-13 (13 C) MR spectroscopy (MRS) is capable of measuring energy metabolism and neuroenergetics, noninvasively in the brain. Indirect (1 H-[13 C]) MRS provides sensitivity benefits compared with direct 13 C methods, and normally includes a 1 H surface coil for both localization and signal reception. The aim was to develop a coil platform with homogenous B1+ and use short conventional pulses for short echo time proton observed carbon edited (POCE) MRS.


A 1 H-[13 C] MRS coil platform was designed with a volumetric resonator for 1 H transmit, and surface coils for 1 H reception and 13 C transmission. The Rx-only 1 H surface coil nullifies the requirement for a T/R switch before the 1 H preamplifier; the highpass filter and preamplifier can be placed proximal to the coil, thus minimizing sensitivity losses inherent with POCE-MRS systems described in the literature. The coil platform was evaluated with a PRESS-POCE sequence (TE = 12.6 ms) on a rat model.


The coil provided excellent localization, uniform spin nutation, and sensitivity. 13 C labeling of Glu-H4 and Glx-H3 peaks, and the Glx-H2 peaks were observed approximately 13 and 21 min following the infusion of 1-13 C glucose, respectively.


A convenient and sensitive platform to study energy metabolism and neurotransmitter cycling is presented. Magn Reson Med 79:628-635, 2018. © 2017 International Society for Magnetic Resonance in Medicine.


1H-[13C] MRS; POCE; PRESS-POCE; [1-13C] glucose infusion; localized 13C edited MRS; short TE

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