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J Infect Dis. 2017 Jun 1;215(11):1720-1724. doi: 10.1093/infdis/jix204.

Fetal Growth Restriction Caused by Sexual Transmission of Zika Virus in Mice.

Author information

1
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine.
2
Department of Immunobiology.
3
Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut.
4
Howard Hughes Medical Institute, Chevy Chase, Maryland.

Abstract

Zika virus (ZIKV) can be transmitted by mosquito bite or sexual contact. Using mice that lack the type I interferon receptor, we examined sexual transmission of ZIKV. Electron microscopy analyses showed association of virions with developing sperm within testes as well as with mature sperm within epididymis. When ZIKV-infected male mice were mated with naive female mice, the weight of fetuses at embryonic day 18.5 was significantly reduced compared with the control group. Additionally, we found ocular deformities in a minority of the fetuses. These results suggest that ZIKV causes fetal abnormalities after female mating with an infected male.

KEYWORDS:

Zika virus; electron microscopy; fetal growth abnormalities; sexual transmission

PMID:
28472297
PMCID:
PMC5853330
DOI:
10.1093/infdis/jix204
[Indexed for MEDLINE]
Free PMC Article

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