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BMC Med Genet. 2017 May 2;18(1):46. doi: 10.1186/s12881-017-0410-y.

Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population.

Author information

1
Consorcio Genómica Computacional, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
2
Laboratorio de Genómica de Enfermedades Cardiovasculares, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
3
Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM-INMEGEN, Mexico City, Mexico.
4
Laboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
5
Hospital Regional "Primero de Octubre", Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico.
6
Department of Agronomy and Horticulture, University of Nebraska, Lincoln, NE, USA.
7
Hospital Regional "Lic. Adolfo López Mateos", Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, Mexico.
8
Departamento de Endocrinología, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico City, Mexico.
9
Departamento de Biología Molecular, Instituto Nacional de Cardiologia "Ignacio Chávez", Mexico City, Mexico.
10
Clínica Integral de Cirugía para la Obesidad y Enfermedades Metabólicas, Hospital Rubén Leñero, Mexico City, Mexico.
11
Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico.
12
Unidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, Cuernavaca, Morelos, Mexico.
13
Laboratorio de Enfermedades Mendelianas, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
14
Consorcio Genómica Computacional, Instituto Nacional de Medicina Genómica, Mexico City, Mexico. sromero@inmegen.gob.mx.

Abstract

BACKGROUND:

The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations.

METHODS:

A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression.

RESULTS:

FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings.

CONCLUSIONS:

This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. Further studies are needed to confirm this interaction.

KEYWORDS:

Body mass index; FTO and ABCA1 variants; Interaction

PMID:
28464932
PMCID:
PMC5414298
DOI:
10.1186/s12881-017-0410-y
[Indexed for MEDLINE]
Free PMC Article

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