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Philos Trans R Soc Lond B Biol Sci. 2017 Jun 5;372(1722). pii: 20160117. doi: 10.1098/rstb.2016.0117.

Lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control.

Author information

1
Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, CA 95064, USA akilpatr@ucsc.edu.
2
School of GeoSciences, University of Edinburgh, Edinburgh, UK.
3
Department of Fisheries and Wildlife, Oregon State University, Corvallis, OR 97331, USA.
4
Department of Biology, Colorado State University, Fort Collins, CO 80523, USA.
5
Department of Biology, San Francisco State University, San Francisco, CA 94132, USA.
6
USGS Patuxent Wildlife Research Center, RI Field Station, University of Rhode Island, Kingston, RI 02881, USA.
7
Vector-Borne Disease Section, Division of Communicable Disease Control, California Department of Public Health, Center for Infectious Diseases, Sacramento, CA 95814, USA.
8
Department of Plant and Environmental Science, University of Copenhagen, 1871 Frederiksberg C, Denmark.
9
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, USA.
10
Public Health Risk Sciences, National Microbiology Laboratory, Public Health Agency of Canada, 3200 Sicotte, Saint-Hyacinthe, Quebec, J2S 7C6, Canada.
11
Department of Ecology, Evolution and Environmental Biology, Columbia University, New York, NY 10027, USA.

Abstract

Lyme disease is the most common tick-borne disease in temperate regions of North America, Europe and Asia, and the number of reported cases has increased in many regions as landscapes have been altered. Although there has been extensive work on the ecology and epidemiology of this disease in both Europe and North America, substantial uncertainty exists about fundamental aspects that determine spatial and temporal variation in both disease risk and human incidence, which hamper effective and efficient prevention and control. Here we describe areas of consensus that can be built on, identify areas of uncertainty and outline research needed to fill these gaps to facilitate predictive models of disease risk and the development of novel disease control strategies. Key areas of uncertainty include: (i) the precise influence of deer abundance on tick abundance, (ii) how tick populations are regulated, (iii) assembly of host communities and tick-feeding patterns across different habitats, (iv) reservoir competence of host species, and (v) pathogenicity for humans of different genotypes of Borrelia burgdorferi Filling these knowledge gaps will improve Lyme disease prevention and control and provide general insights into the drivers and dynamics of this emblematic multi-host-vector-borne zoonotic disease.This article is part of the themed issue 'Conservation, biodiversity and infectious disease: scientific evidence and policy implications'.

KEYWORDS:

Borrelia burgdorferi; Ixodes; dilution effect; emerging infectious disease; epidemiology

PMID:
28438910
PMCID:
PMC5413869
[Available on 2018-06-05]
DOI:
10.1098/rstb.2016.0117
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