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Transpl Infect Dis. 2017 Aug;19(4). doi: 10.1111/tid.12704. Epub 2017 Jun 1.

Fatal case of cutaneous-sparing orolaryngeal zoster in a renal transplant recipient.

Author information

1
Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT, USA.
2
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.
3
Department of Surgical Pathology, Yale University School of Medicine, New Haven, CT, USA.
4
Department of Surgery (Transplant), Yale University School of Medicine, New Haven, CT, USA.

Abstract

Herpesvirus infections in solid organ transplant (SOT) recipients are a significant cause of morbidity and mortality. We report a case of herpes zoster (HZ) in a kidney transplant recipient while receiving belatacept, a CTLA-4 inhibitor that prevents acute rejection. The patient presented with oropharyngolaryngeal mucosal lesions that subsequently disseminated resulting in pneumonitis and meningo-encephalitis. Very late-onset HZ can occur and can present atypically in SOT recipients. Delayed recognition and treatment may result in poor outcomes, as illustrated by this case.

KEYWORDS:

disseminated VZV; kidney transplant; late-onset infection

PMID:
28401625
DOI:
10.1111/tid.12704
[Indexed for MEDLINE]

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