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Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Mar;2(2):188-195. doi: 10.1016/j.bpsc.2016.03.001.

Shared microstructural features of behavioral and substance addictions revealed in areas of crossing fibers.

Author information

1
CASAColumbia, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
2
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
3
Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA.
4
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Connecticut Mental Health Center, New Haven, CT, USA.
5
CASAColumbia, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Connecticut Mental Health Center, New Haven, CT, USA; Department of Neurobiology, Yale University School of Medicine, New Haven, CT, USA; Yale Child Study Center, Yale University School of Medicine, New Haven, CT, USA.

Abstract

BACKGROUND:

Similarities between behavioral and substance addictions exist. However, direct neurobiological comparison between addictive disorders is rare. Determination of disorder-specificity (or lack thereof) of alterations within white-matter microstructures will advance understanding of the pathophysiology of addictions.

METHODS:

We compared white-matter microstructural features between individuals with gambling disorder (GD; n=38), cocaine-use disorder (CUD; n=38) and healthy comparison (HC; n=38) participants, as assessed using diffusion-weighted magnetic resonance imaging (dMRI). To provide a more precise estimate of diffusion within regions of complex architecture (e.g., cortico-limbic tracts), analyses were conducted using a crossing-fiber model incorporating local-orientation modeling (tbss_x). Anisotropy estimates for primary and secondary fiber orientations were compared using ANOVAs corrected for multiple comparisons across space using threshold-free cluster enhancement (pFWE<.05).

RESULTS:

A main effect of group on anisotropy of secondary fiber orientations within the left internal capsule, corona radiata, forceps major and posterior thalamic radiation, involving reduced anisotropy among GD and CUD participants in comparison to HC participants. No differences in anisotropy measures were found between GD and CUD individuals.

CONCLUSIONS:

This is the first study to compare diffusion indices directly between behavioral and substance addictions and the largest dMRI study of GD. Our findings indicate similar white-matter microstructural alterations across addictions that cannot be attributed solely to exposure to drugs or alcohol and thus may be a vulnerability mechanism for addictive disorders.

KEYWORDS:

alcohol-use disorder; behavioral addiction; diffusion tensor imaging (DTI); impulsivity; pathological gambling; substance-use disorder

PMID:
28367515
PMCID:
PMC5373810
[Available on 2018-03-01]
DOI:
10.1016/j.bpsc.2016.03.001
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