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Circ Res. 2017 Mar 31;120(7):1174-1182. doi: 10.1161/CIRCRESAHA.117.303776.

Contemporary Approaches to Modulating the Nitric Oxide-cGMP Pathway in Cardiovascular Disease.

Author information

1
From the Vascular Biology and Therapeutics Program (J.R.K.) and Department of Pharmacology (W.C.S.), Yale University, School of Medicine, New Haven, CT.
2
From the Vascular Biology and Therapeutics Program (J.R.K.) and Department of Pharmacology (W.C.S.), Yale University, School of Medicine, New Haven, CT. william.sessa@yale.edu.

Abstract

Endothelial cells lining the vessel wall control important aspects of vascular homeostasis. In particular, the production of endothelium-derived nitric oxide and activation of soluble guanylate cyclase promotes endothelial quiescence and governs vasomotor function and proportional remodeling of blood vessels. Here, we discuss novel approaches to improve endothelial nitric oxide generation and preserve its bioavailability. We also discuss therapeutic opportunities aimed at activation of soluble guanylate cyclase for multiple cardiovascular indications.

KEYWORDS:

caveolin-1; endothelial cells; heart failure; nitrates; nitric oxide

PMID:
28360348
PMCID:
PMC5391494
DOI:
10.1161/CIRCRESAHA.117.303776
[Indexed for MEDLINE]
Free PMC Article

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