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JMM Case Rep. 2016 Feb 18;3(1):e005018. doi: 10.1099/jmmcr.0.005018. eCollection 2016 Feb.

Aspergillus fumigatus native valve infective endocarditis in an otherwise healthy adult.

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Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine , New Haven, CT 6520 , USA.



Fungal endocarditis is a rare cause of infective endocarditis, and Aspergillus spp. account for up to 30 % of all cases. Risk factors include intravenous drug use, immunosuppression, malignancy and the presence of prosthetic valves.


We present a case of A. fumigatus endocarditis in a patient without any known or described risk factors.


Diagnosis of Aspergillus endocarditis requires a high clinical index of suspicion, given the initial non-specific presentation, and treatment may require both medical and surgical therapies to ensure improved outcomes, but mortality rates still approach 80 %. Voriconazole remains the antifungal agent of choice.


Aspergillus fumigatus; fungal endocarditis; native valve endocarditis

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