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Curr Cardiol Rep. 2017 Apr;19(4):34. doi: 10.1007/s11886-017-0841-2.

Stem Cells in Cardiovascular Medicine: the Road to Regenerative Therapies.

Anderson CW1,2, Boardman N1,3, Luo J1,3, Park J1,3, Qyang Y4,5,6,7.

Author information

1
Vascular Biology and Therapeutics Program, Yale University, New Haven, CT, 06510, USA.
2
Molecular Cell Genetics and Developmental Biology Program, Yale University, New Haven, CT, 06510, USA.
3
Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, Yale School of Medicine, 300 George Street, Ste 773A, New Haven, CT, 06511, USA.
4
Vascular Biology and Therapeutics Program, Yale University, New Haven, CT, 06510, USA. yibing.qyang@yale.edu.
5
Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, Yale School of Medicine, 300 George Street, Ste 773A, New Haven, CT, 06511, USA. yibing.qyang@yale.edu.
6
Yale Stem Cell Center, Yale University, New Haven, CT, 06510, USA. yibing.qyang@yale.edu.
7
Department of Pathology, Yale University, New Haven, CT, 06510, USA. yibing.qyang@yale.edu.

Abstract

PURPOSE OF REVIEW:

The purpose of this review is to provide a broad overview of current trends in stem cell research and its applications in cardiovascular medicine. Researches on different stem cell sources, their inherent characteristics, and the limitations they have in medical applications are discussed. Additionally, uses of stem cells for both modeling and treating cardiovascular disease are discussed, taking note of the obstacles these engineered interventions must overcome to be clinically viable.

RECENT FINDINGS:

Tissue engineering aims to replace dysfunctional tissues with engineered constructs. Stem cell technologies have been a great enabling factor in working toward this goal. Many tissue-engineered products are in development that utilize stem cell technology. Although promising, some refinement must be made to these constructs with respect to safety and functionality. A deeper understanding of basic differentiation and tissue developmental mechanisms is required to allow these engineered tissues to be translated into the clinic.

KEYWORDS:

Cardiovascular; Embryonic stem cells; Induced pluripotent stem cells; Regenerative medicine; Stem cells; Tissue engineering

PMID:
28324469
DOI:
10.1007/s11886-017-0841-2
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